All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

Started by ACARE in 2023 within the ACARELevelUp program this podcast is an invaluable resource for health care professionals, and anyone interested in learning more about angioedema. Dr. Thomas Buttgereit, Head of the Study Center at Charité Berlin, discusses all forms of angioedema, their pathophysiology, burden and treatment strategies with experts from all over the world. All opinions expressed are those of the faculty. This content should not be taken as medical advice and is for informational purposes only. Learn more about ACARE here: https://acare-network.com/

All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit is a education podcast hosted by Dr. Thomas Buttgereit, with 52 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Dr. Thomas Buttgereit hosts All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit, a education show with 52 episodes published.

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  All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

  Facial Swelling: Finding the Diagnosis

  Aug 18, 202623 min

  In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with dermatologist Dr. Natasha Teovska Mitrevska from North Macedonia about one of the biggest challenges in clinical practice: distinguishing angioedema from other conditions that cause facial or tissue swelling. Drawing on her experience in both medical and aesthetic dermatology, she explains common differential diagnoses and discusses how cosmetic procedures can trigger swelling that resembles angioedema. They discuss: Which conditions commonly mimic angioedema? How can cosmetic and aesthetic procedures trigger swelling? Which forms of chronic inducible urticaria may occur after aesthetic treatments? Why is careful patient history essential before cosmetic procedures? How can clinicians distinguish inflammatory swelling from true angioedema? What should patients and practitioners know about fillers and delayed reactions? The episode highlights the importance of careful clinical assessment, patient history, and awareness of differential diagnoses to ensure patients receive the correct diagnosis and treatment while safely undergoing dermatological and aesthetic procedures. Key Learnings from the Episode: Not every facial swelling is angioedema. Several skin diseases and infections can mimic angioedema. A thorough medical history is essential before cosmetic procedures. Laser treatments, fillers, and other aesthetic procedures can trigger temporary swelling. Patients with chronic urticaria or inducible urticaria may have a higher risk of procedure-related reactions. Different types of chronic inducible urticaria can be triggered by physical stimuli during aesthetic treatments. Delayed inflammatory reactions after fillers require careful evaluation. Accurate diagnosis helps distinguish true angioedema from cosmetic treatment-related swelling. Close collaboration between dermatologists and allergy specialists improves patient safety. Chapters: 00:00 Introduction to the episode and guest 01:08 Guest introduction and practice background 04:20 Common differential diagnoses for facial swelling 06:22 Swelling duration and laser hair removal 07:45 Inflammatory swelling from aesthetic procedures 09:25 Other differential diagnoses: lupus, rosacea, drug reactions 12:22 Impact of chronic conditions and medication on swelling 16:32 Allergic reactions to fillers and aesthetic materials 18:23 Perception of beauty and filler overfilling 21:24 Balancing aesthetic goals with safety considerations 22:22 Closing remarks and contact information Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Feedback form ATA: ⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠https://forms.office.com/e/ZWxx3D4Cmr⁠⁠

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  All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

  Challenges and Opportunities in Kenya

  Jul 14, 202620 min

  In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with Dr. Priya Bowry Sikand from Nairobi, Kenya, leader of one of the newest ACARE centers in Africa. Together, they discuss the unique challenges of diagnosing and managing angioedema in East and Central Africa, as well as the opportunities to improve care through education and collaboration. They discuss: 🔹 Which types of angioedema are most commonly seen in Kenya and the surrounding region? 🔹 How do chronic infections contribute to angioedema and urticaria presentations? 🔹 Why are food-related and aeroallergen-associated angioedema cases particularly relevant in this setting? 🔹 What are the current challenges in diagnosing hereditary angioedema (HAE) in Africa? 🔹 How limited is access to specialized testing and modern HAE therapies? 🔹 What role do education, awareness, and ACARE play in improving patient outcomes? Dr. Bowry Sikand shares insights from her clinical experience and highlights the significant unmet needs in HAE care across sub-Saharan Africa. The conversation emphasizes the importance of physician education, improved diagnostic pathways, and equitable access to effective treatments for patients living with recurrent angioedema. Key Learnings from the Episode: Chronic infections are a common cause of angioedema and urticaria in East Africa. Food-related angioedema is frequently encountered in clinical practice. House dust mite allergy can contribute to recurrent facial angioedema. HAE remains significantly underdiagnosed across sub-Saharan Africa. Access to C1 inhibitor testing is limited and often expensive. Modern HAE treatments are not widely available in many African countries. Many patients rely on older therapies such as danazolandrogens and tranexamic acid. Education and awareness are essential for improving HAE diagnosis. International collaboration helps expand access to expertise and training. Patients with HAE could achieve much better outcomes with improved access to diagnostics and treatment. Chapters: 00:00 Introduction to the episode and guest 00:42 Guest introduction and regional context 02:30 Common angioedema cases in Kenya 03:28 Diverse patient population and regional differences 04:27 Infections and their role in angioedema 05:24 Food allergies, especially meat, in Kenya 06:24 Environmental factors and aeroallergens 07:11 Infectious disease testing and treatment strategies 08:33 Treatment options and access challenges 11:28 Hereditary angioedema (HAE) in Kenya 12:03 Diagnostic challenges and resource limitations 14:03 Treatment access and regional disparities 16:42 Training, education, and future prospects 18:05 Final thoughts and call for global support Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Feedback form ATA: ⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠https://forms.office.com/e/ZWxx3D4Cmr⁠⁠

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  All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

  Treat-to-Target in Hereditary Angioedema

  Jun 9, 202616 min

  In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with Dr. Isabelle Boccon-Gibod from the French ACARE center in Grenoble about the new European expert consensus on applying a treat-to-target (T2T) approach in hereditary angioedema (HAE). The discussion explores how goal-oriented care can improve consistency and patient outcomes in daily clinical practice. They discuss: 🔹 What does a treat-to-target approach mean in HAE management? 🔹 How does T2T differ from traditional guideline-based treatment? 🔹 What are the short-term and long-term goals in HAE care? 🔹 Why are patient-reported outcome measures (PROMs) so important? 🔹 What challenges exist when implementing T2T in clinical practice? 🔹 How could this consensus influence future guidelines and research? Dr. Boccon-Gibod explains how structured monitoring, shared decision-making, and clearly defined treatment goals can help move HAE care closer to the ultimate aim of “normalization of life.” The episode highlights the importance of individualized care and practical strategies for improving disease control and quality of life. Key Learnings from the Episode: Treat-to-target introduces a structured, goal-oriented approach to HAE care. The approach combines short-term symptom control with long-term quality-of-life goals. Normalization of life is the ultimate treatment target in HAE. Patient-reported outcome measures are central to monitoring disease control. The AECT is an important tool for assessing HAE control in practice. Shared decision-making plays a key role in treatment planning. Clinical practice and access to therapies still vary across countries. Structured follow-up can improve consistency of care. T2T may influence future HAE guidelines and clinical research. The approach aims to improve long-term outcomes for patients with HAE. Chapters: 00:00 Introduction to Angioedema and the Podcast 01:04 Understanding the Treat-to-Target Approach 02:15 The Role of Patient-Reported Outcome Measures 10:19 Challenges in Implementing the T2T Approach 12:16 Impact of Consensus on Future Research and Guidelines Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Feedback form ATA: ⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠https://forms.office.com/e/ZWxx3D4Cmr⁠⁠

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  All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

  Patient Advocacy in HAE: Voices That Matter

  May 12, 202621 min

  In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with Patricia Karani, patient advocate from Kenya, about her personal journey with hereditary angioedema (HAE) and her work supporting patients across sub-Saharan Africa. Recorded in the context of the Global Angioedema Leadership Conference (GALC), this episode brings a powerful patient perspective to the discussion. They discuss: 🔹 What is it like to live with undiagnosed HAE for decades? 🔹 Why is delayed diagnosis still a major challenge worldwide? 🔹 What barriers do patients face in accessing life-saving treatments? 🔹 How can patient advocacy help improve awareness and healthcare systems? 🔹 Why is collaboration with governments essential for access to therapies? 🔹 How can patients become advocates and drive change in their regions? Patricia shares her story of nearly 30 years without proper diagnosis or treatment, and how this experience shaped her mission to support others. The episode highlights the importance of awareness, building patient networks, and advocating for better access to treatment—especially in regions where rare diseases are often overlooked. Key Learnings from the Episode: HAE diagnosis can be delayed for decades, leading to significant suffering. Misdiagnosis as allergies is common and delays proper treatment. Access to HAE therapies remains a major challenge in many regions. Patient advocacy is essential to raise awareness and improve care. Collaboration with governments is key to making treatments affordable. Building patient networks helps identify and support affected individuals. Education of healthcare professionals is critical for earlier diagnosis. Living with controlled HAE enables patients to live a full life. Personal experiences can be a powerful driver for advocacy. Global collaboration strengthens patient support and healthcare improvements. Chapters: 00:00 Introduction to Angioedema and the Podcast 01:51 Patient Advocacy and the Global Angioedema Leadership Conference 06:40 Patricia's Journey with Hereditary Angioedema 10:15 Challenges in Patient Advocacy and Awareness 17:03 Motivation Behind Patient Advocacy and Living Fully Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Feedback form ATA: ⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://forms.office.com/e/ZWxx3D4Cmr⁠⁠

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  All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

  Early Diagnosis of HAE in Newborns

  Apr 14, 202623 min

  In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with Dr. Lili Voloncs-Mindszenthy from Semmelweis University, Hungary, recipient of the Young Investigator Award at the Global Angioedema Leadership Conference (GALC) 2026. They discuss her groundbreaking research on improving the early diagnosis of hereditary angioedema (HAE) in newborns. They discuss: 🔹 Why is diagnosing HAE in newborns particularly challenging? 🔹 Which complement biomarkers can reliably indicate HAE from birth? 🔹 Why are C1 inhibitor levels and function more informative than other complement factors? 🔹 What are the limitations of current diagnostic approaches, including genetic testing? 🔹 How can early diagnosis improve patient outcomes and family screening? 🔹 What are the next steps in validating these findings for clinical use? Dr. Voloncs-Mindszenthy shares insights from her study using umbilical cord blood samples, identifying consistent patterns in C1 inhibitor levels and function that may allow for much earlier diagnosis of HAE. The episode highlights the potential to move diagnosis closer to birth and improve early intervention strategies. Key Learnings from the Episode: Diagnosing HAE in newborns is challenging due to an immature complement system. Early diagnosis is crucial, especially in families with known HAE history. C1 inhibitor antigenic levels and function show consistent patterns in HAE newborns. These parameters may serve as reliable early biomarkers for HAE. Other complement factors such as C3 and C4 show high variability and are less reliable. Genetic testing is useful but not always readily available or practical. Umbilical cord blood testing offers a practical early diagnostic opportunity. Larger studies are needed to establish newborn-specific reference ranges. Early detection can improve patient management and enable family screening. The research highlights a promising step toward diagnosing HAE from birth. Chapters: 00:00 Introduction to Angioedema and the Conference Highlights 05:15 Lily's Background and Research Journey 09:55 Insights from the Global Angioedema Leadership Conference 14:07 Research on Diagnosing HAE in Newborns 18:29 Future Directions and Conclusion Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Feedback form ATA: ⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠https://forms.office.com/e/ZWxx3D4Cmr⁠⁠

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