Decoding Longevity

A podcast dedicated to unraveling the mysteries of aging through the lens of cutting-edge science. Each episode breaks down the latest research papers in the field of geroscience, offering clear, insightful discussions on longevity, biological aging, and the quest for extending healthspan. Perfect for scientists, enthusiasts, and anyone curious about the science behind living longer and healthier lives.

Decoding Longevity is a health podcast hosted by Raghav Sehgal, with 31 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Raghav Sehgal hosts Decoding Longevity, a health show with 31 episodes published.

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  Episode #31

  Moving Beyond Mortality Clocks: Responsive Rate of Aging Biomarkers with Associate Professor Dan Belsky

  Aug 5, 202647 min

  Can two people of the same age be aging at completely different speeds? In this episode, Dr. Raghav Sehgal and Dr. Macsue Jacques speak with Associate Professor Daniel W. Belsky about the science behind DunedinPACE and why measuring the pace of aging may be more valuable than estimating biological age. The conversation covers the Dunedin Study, aging biomarkers, the CALERIE trial, and the ARPA-H FAST Initiative—offering a look at how researchers are building the next generation of tools to evaluate longevity interventions. Follow Decoding Longevity for more conversations with leading researchers shaping the future of healthy aging.

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  Episode #30

  Testing the Longevity Promise: What Mice Can Really Teach Us About Slowing Ageing — A Conversation with Professor Richard Miller

  Jul 22, 202648 min

  Can we really slow biological aging? In this episode of Decoding Longevity , Professor Richard A. Miller—Professor of Pathology at the University of Michigan and a founding leader of the National Institute on Aging's Interventions Testing Program (ITP) —joins us to explore how scientists determine whether a longevity intervention truly works. From rapamycin and acarbose to biomarkers, healthspan, and the challenges of translating mouse studies into human medicine, this conversation examines what decades of rigorous research reveal about slowing aging—and why evidence matters more than hype.

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  Episode #29

  Longevity for Everyone: HIV, Prevention, and the Future of Global Healthy Aging — A Conversation with Professor Linda-Gail Bekker

  Jul 1, 202631 min

  What if the greatest breakthrough in longevity isn't slowing aging—but preventing disease before it begins? In this episode of Decoding Longevity , we speak with Professor Linda-Gail Bekker , one of the world's leading experts in HIV prevention, tuberculosis research, and global public health. Together, we explore how HIV research has transformed our understanding of longevity, from restoring life expectancy through antiretroviral therapy to preventing infection with groundbreaking advances like Lenacapavir . We discuss healthspan versus lifespan, chronic inflammation, accelerated biological aging, health equity, and why prevention may be the most powerful longevity intervention of all. This conversation offers a compelling look at how advances in infectious disease research are shaping the future of healthy aging.

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  Episode #28

  What Can Hibernating Squirrels Teach Us About Aging, Disease, and Human Health?: A Conversation With Dr. Ashley Zehnder

  Jun 10, 202627 min

  What can hibernating squirrels teach us about aging, disease, and human health? In Episode 28 of Decoding Longevity, we sit down with Dr. Ashley Zehnder, Co-Founder and CEO of Fauna Bio, to explore how evolution-driven drug discovery is uncovering new therapeutic opportunities for some of humanity’s most challenging diseases. Ashley explains how animals that naturally withstand oxygen deprivation, prevent fibrosis, rebuild tissues, and resist neurodegeneration may hold the key to future treatments for heart failure, metabolic disease, and age-related decline. We discuss hibernation biology, comparative genomics, AI-powered drug discovery, regenerative medicine, and how nature’s most resilient species are helping scientists identify novel therapeutic targets. Key topics include: • Hibernation as a model for regeneration and tissue repair • Comparative biology and longevity science • AI, genomics, and evolution-driven drug discovery • Brain resilience and neurodegenerative disease • Heart failure therapeutics inspired by nature • The future of biotechnology and healthy aging Guest: Dr. Ashley Zehnder Co-Founder & CEO, Fauna Bio Hosts: Dr. Raghav Sehgal & Dr. Macsue Jacques Fauna Bio: https://www.faunabio.com/ Ashley’s Talks https://www.youtube.com/watch?v=WX-ulloH08w https://www.youtube.com/watch?v=kmowQzL_VjY https://www.youtube.com/watch?v=C9cy7vyTUGs

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  Episode #27

  Metabolism, Immunity & the Biology of Aging: A Conversation with Dr. Eric Verdin

  May 27, 202650 minS0

  <p>What if aging is not just damage — but a biologically regulated process shaped by metabolism, inflammation, and gene expression?</p><p>In this episode of Decoding Longevity, Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging, joins us for a wide-ranging conversation on the molecular biology of aging.</p><p>We explore how metabolism influences epigenetics, why immune aging may be central to healthspan, and what today’s longevity science actually tells us about extending healthy human life.</p><p>From NAD+ and ketone bodies to inflammaging, biomarkers, rapamycin, metformin, and epigenetic reprogramming, this epis...

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