Inflammatory Content

Inflammatory Content is a podcast about immunology and biomedical sciences more broadly. UC San Diego immunologist Dr. Kellen Cavagnero PhD reviews the latest high-impact original articles and discusses all things science with leading researchers in the field. Inflammatory Content has been featured in Nature and received sponsorship from the NIH.

Inflammatory Content is a science podcast hosted by Kellen Cavagnero, Ph.D., with 28 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Kellen Cavagnero, Ph.D. hosts Inflammatory Content, a science show with 28 episodes published.

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  Inflammatory Content

  #28: Hidradenitis Suppurativa

  Jan 3, 202639 minS0

  <p>In this episode of Inflammatory Content, Dr. Kellen Cavagnero explores the debilitating skin disease hidradenitis suppurativa (HS) and takes a deep dive into a recent Immunity paper that comprehensively examines the role of tertiary lymphoid structures in HS pathogenesis. HS has long defied simple classification, with prevailing disease models emphasizing hair follicle dysfunction, aberrant wound healing, or chronic inflammation. This work adds a new dimension by implicating autoimmunity as a central contributor to HS pathogenesis, further underscoring the complexity of the disease.</p><p><br></p><p>Relevant Links:</p><p>• Paper: https://pmc.ncbi.nlm.nih.gov/articles/PM...

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  Inflammatory Content

  #27: A Surprising New Role for Neutrophils in Wound Healing

  Aug 19, 202530 minS0

  <p>In this episode of Inflammatory Content, Dr. Kellen Cavagnero breaks down a new Nature paper showing that a subset of skin neutrophils doesn’t just fight bacteria—they also build extracellular matrix (ECM). After injury, these neutrophils rapidly assemble rings of ECM around the wound that strengthen the barrier and limit bacterial entry. This program depends on TGF-β signaling within neutrophils; when that pathway is disabled, the rings fail to form and bacteria penetrate more easily. </p><p><br></p><p>Relevant Links:</p><p>• Paper: https://pubmed.ncbi.nlm.nih.gov/40108463/</p><p>• Commentary: https://www.nature.com/articles...

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  Inflammatory Content

  #26: Spatial Proteomics Uncovers a Lifesaving Treatment for Severe Skin Drug Reactions

  Jul 5, 202519 minS0

  <p>In this episode of Inflammatory Content, Dr. Kellen Cavagnero dives into a landmark 2024 Nature study by Thierry Nordman and colleagues, titled “Spatial proteomics identifies JAKi as treatment for a lethal skin disease.” This cutting-edge research changes the game for patients suffering from toxic epidermal necrolysis (TEN)—a devastating cutaneous adverse drug reaction with limited treatment options.</p><p><br></p><p>Using a powerful approach including spatial proteomics and mouse models of TEN, the authors identify interferon signaling as a key inflammatory pathway driving TEN. Most remarkably, they repurpose an FDA-approved JAK inhibitor to safely and effectively treat patients with T...

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  Inflammatory Content

  #25: Immuno-endocrinology with Dr. Dequina Nicholas, Ph.D.

  Mar 7, 20251h 9mS0

  <p>In this episode, Dr. Kellen Cavagnero is joined by Dr. Dequina Nicholas. Dr. Nicholas is an Assistant Professor at the University of California Irvine in the Department of Molecular Biology and Biochemistry. Her laboratory studies endocrine diseases, including type 2 diabetes and polycystic ovary syndrome. Specifically, her group investigates the intersection of the nutrient environment, the immune system, and metabolic disease using a combination of molecular and cellular biology, transgenic mouse models, cytokine profiling, and flow cytometry. Dr. Nicholas is the recipient of numerous awards including the NIH Director’s New Innovator Award. </p><p>In their conversation, Kellen and De...

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  Inflammatory Content

  #24: AI Generated Podcast on Immune-Acting Fibroblasts

  Jan 15, 202533 minS0

  <p>Today we’re going to do a journal club, but it will not be your run of the mill journal club. Everyone who knows me knows I am always searching for the latest technology that can increase my efficiency. Lately, I have been especially attuned to the newest developments in artificial intelligence.Well, I recently discovered a new AI tool by Google called NotebookLM that creates audio overviews of documents. What this means is that it will--within minutes--create a journal club podcast if you upload a research article. It is BANANAS! </p><p>There are a few minor instances wh...

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