Longevity Optimization with Kayla Barnes-Lentz

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

Longevity Optimization with Kayla Barnes-Lentz is a health podcast hosted by Kayla Barnes-Lentz, with 165 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Kayla Barnes-Lentz hosts Longevity Optimization with Kayla Barnes-Lentz, a health show with 165 episodes published.

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  Longevity Optimization with Kayla Barnes-Lentz

  Dr. Christin Glorioso, MD, PhD: The Alzheimer's Blood Test, How to Cut Your Dementia Risk by 30%, and Why Women Are at Higher Risk

  Aug 6, 20261h 12m

  Brain aging does not start when memory loss shows up. It starts around age 25, decades before anyone notices anything is different. By the time a symptom appears, the window for the highest-leverage prevention has usually already closed. Today I'm talking with Dr. Christin Glorioso, an MD and PhD who has spent her career studying Alzheimer's, partly because of her own family history and partly because she carries the ApoE4 gene herself. She has since used her own brain scans, blood work, and lifestyle changes to lower her own brain age, and she's built a company around helping other people do the same. This conversation covers what actually causes Alzheimer's versus what we got wrong for decades, why the brain can grow back the same way muscle does, and why a ten minute daily habit has better evidence behind it than any drug currently on the market. We also get into hormone therapy, cholesterol, the ketogenic diet, and why women are so consistently underserved on all three. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Christin Glorioso, MD, PhD LinkedIn: https://www.linkedin.com/in/christin-glorioso-md-phd-39627719/ Website: https://www.neuroagetx.com/ #BrainHealth #AlzheimersPrevention #DementiaPrevention #BrainAging #Neuroscience #CognitiveHealth #HRT #Perimenopause #Menopause #Cholesterol #Nootropics

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  Longevity Optimization with Kayla Barnes-Lentz

  Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection

  Jul 30, 20261h 18m

  Most people think of the gut as a digestive organ. It is not. It is the upstream controller of your metabolism, immune function, brain health, skin, and hormones and almost everyone is running it on a depleted, misfed microbiome without knowing it. Dr. Colleen Cutcliffe, PhD is the co-founder and CEO of Pendulum Therapeutics, holds a PhD in biochemistry from Johns Hopkins, and spent over 15 years in pharma and biotech before pioneering next-generation probiotic science. Her team was the first in the world to manufacture Akkermansia, a strain found at high levels in virtually every centenarian population studied and depleted in almost every major chronic disease. What makes this conversation different from most gut health discussions is the level of scientific rigor behind it. This is not wellness theory. This is published research, clinical data, and a decade of actually building the science from the ground up. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member In this conversation we explore: How your gut produces its own GLP-1 naturally and why synthetic versions may blunt that system over time Why Akkermansia is elevated in centenarians and depleted across virtually every chronic disease The fiber gap: 95% of people are under-threshold and it is driving metabolic and colon health decline What early antibiotic use does to the microbiome and how to rebuild at any age Why soap may be fueling the allergy and asthma epidemic by stripping the skin's protective barrier How butyrate links gut health, colon cancer risk, and natural GLP-1 production Why most probiotics on Amazon do not contain what the label claims Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Coleen Instagram: https://www.instagram.com/drcolleencutcliffe/ Pendulum Life Instagram: https://www.instagram.com/pendulumlifeco/ Website: https://pendulumlife.com/

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  Longevity Optimization with Kayla Barnes-Lentz

  Dr. Elizabeth Yurth, MD: Muscle Building in Midlife, Joint Regeneration, Peptide Protocols, and Why Osteoarthritis Is Not Wear and Tear

  Jul 2, 20262h 41m

  Dr. Elizabeth Yurth, co-founder of Boulder Longevity Institute, is one of the rare physicians who spent 30 years in orthopedic and sports medicine before pivoting to longevity and regenerative medicine. This episode covers joint health in women, osteoarthritis, bone density, peptides, perimenopause, hormones, mitochondrial health, and the regenerative protocols most women have never been offered. What she found after decades of patching people together: we have been thinking about joint disease completely wrong. Osteoarthritis is not a wear and tear condition. It is a metabolic disease driven by mitochondrial dysfunction, hormonal decline, and chronic low-grade inflammation, and it can be prevented, slowed, and in many cases reversed if you start addressing it at the root. Most women wait until something breaks before paying attention. By then, the damage has been building for years. The interventions that actually work are available now. They are just not in the standard conversation. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member In this conversation we explore: Why osteoarthritis is not a wear and tear disease and what the research actually shows How progesterone protects your ligaments, tendons, and bone (and why estrogen gets all the credit) Why birth control creates the perfect storm for joint and ligament injury Why mitochondrial dysfunction is at the root of joint disease, muscle loss, and brain decline and why you have to repair before you rev Hip fractures carry a 25% mortality rate in women, and most have never had a DEXA scan Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Elizabeth Yurth: Website: https://boulderlongevity.com/ Instagram: https://www.instagram.com/dryurth/ YouTube: https://www.youtube.com/@dryurth #longevity #womenslongevity #peptides #jointhealth #bonedensity #musclebuilding #mitochondria #regenerativemedicine #perimenopause #womenshealth #biohacking #osteoarthritis #hormones #longevityoptimization

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  Longevity Optimization with Kayla Barnes-Lentz

  Dr. Wendy Troxel, PhD: Insomnia, Sleep Apnea, Perimenopause Sleep, and the Treatment That Outperforms Every Medication

  Jun 25, 20261h 14m

  Sleep is not just something women need more of. It is something women struggle with in ways that are fundamentally different from men and almost nobody explains why. Dr. Wendy Troxel, PhD is one of the most respected sleep scientists in the world. Her research has shaped sleep policy in the US military. Her book, Sharing the Covers, is one of the most practical and science-backed guides to partnered sleep available. She is the rare researcher who can speak to the biology of sleep, the hormonal shifts of perimenopause, and what is actually happening in your bedroom, all in the same conversation. This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off. https://zenbasil.com/shopzenbasil/zenbasilseedbag Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community In this conversation: Why women are twice as likely to have insomnia as men What the new sleep duration research actually says (and why the magic number is not the point) How relationship quality affects women's sleep and long-term health differently than men's Why perimenopause is a perfect storm for sleep disruption The 5 things that most reliably improve sleep quality Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Dr Wendy: Instagram: https://www.instagram.com/drwendytroxel/ Website: https://www.drwendytroxel.com/ LinkedIn: https://www.linkedin.com/in/dr-wendy-troxel Shownotes: Society of Behavioral Sleep Medicine: https://www.behavioralsleep.org Dr. Wendy Troxel's TEDx Talk: https://youtu.be/G0Zj_InJ4BQ?si=4-p3Iac2gItHlxtX

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  Longevity Optimization with Kayla Barnes-Lentz

  Dr. Sharon Horesh Bergquist, MD: Hormetic Stress, Women’s Resilience, and the 5 Stressors That Support Longevity

  Jun 18, 20261h 20m

  Avoiding stress at all costs may actually be making you less resilient. In this episode, Dr. Sharon Horesh Bergquist reframes stress as one of the body’s most overlooked tools for longevity. The right kind of challenge can activate repair, strengthen resilience, improve metabolic health, and help the body adapt in ways that support healthier aging over time. Rather than trying to eliminate stress completely, she explains how to use it more intelligently. At the center of the conversation are five key stressors the body appears designed to benefit from when they’re used well: plant phytochemicals, exercise, heat and cold exposure, time-restricted eating, and purpose-driven psychological stress. Sharon also explains why recovery matters and why too little stress can be just as harmful as too much, and how mindset changes the biology of the stress response. A study of 29,000 people found that believing stress is harmful raised the risk of dying by 43%, while viewing it as not harmful lowered that risk by 17%. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off. https://zenbasil.com/shopzenbasil/zenbasilseedbag In This Conversation: Why the right kind of stress can improve longevity The 5 hormetic stressors that help the body adapt Why recovery matters just as much as challenge Heat, cold, exercise, fasting, and plant compounds through a longevity lens Why modern comfort may be making us less resilient How mindset and purpose change the biology of stress Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Sharon: Instagram: https://www.instagram.com/thegoodstressdoctor/ LinkedIn: https://www.linkedin.com/in/thegoodstressdoctor/ Website: https://drsharonbergquist.com/ Order Her Book - The Stress Paradox: https://drsharonbergquist.com/the-stress-paradox Top 10 Health & Longevity Tests By Dr. Sharon: https://dr-sharon-bergquist.kit.com/ten-tests

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