Longevity Papers Podcast

The Longevity Papers podcast focuses on the latest research papers in longevity biotech. Each episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers.

Longevity Papers Podcast is a technology podcast hosted by Longevity Papers, with 37 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Longevity Papers hosts Longevity Papers Podcast, a technology show with 37 episodes published.

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  Episode #39

  Harvard Finds Aging Microbiome Harms the Brain, Plus 4 More Breakthroughs - Longevity Papers Mar 2026

  Mar 15, 202619 minS0

  In this episode of Longevity Papers, we analyze five standout papers from longevitypapers.com covering the past four weeks of longevity research (February-March 2026): 1) Microbiome depletion rejuvenates the aging brain (Gasperini, Holton, Limone et al., Harvard University, February 15, 2026, bioRxiv, https://www.biorxiv.org/content/10.64898/2026.02.13.705770v1 ) - Antibiotic-induced microbiome depletion in aged mice triggers widespread brain rejuvenation including improved neurogenesis, myelination, vascular density, and memory. The aged gut microbiome drives brain aging through eotaxin-1 (CCL11) - the same factor found elevated in old blood in the classic heterochronic parabiosis studies. Inhibiting eotaxin-1 alone was sufficient to reverse multiple brain aging hallmarks. 2) Transplanting...

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  Episode #38

  H2S Gasotransmitters, Lymphatic Rejuvenation, HIV Cure, and First Human Rapamycin Study - Feb 2026

  Feb 11, 202634 minS0

  In this episode, we discuss five groundbreaking papers from longevitypapers.com on mechanisms of aging and potential interventions: 1) Enhanced non-enzymatic H2S generation via natural diallyl sulforated compounds extends lifespan and healthspan in mice (Cáliz-Molina et al., Cell Metabolism, December 2025, https://pubmed.ncbi.nlm.nih.gov/41421349/ ) - Diallyl sulforated compounds boost endogenous hydrogen sulfide, improving mitochondrial function, suppressing mTOR-related aging pathways, and restoring protein persulfidation in aged mice. This non-pharmacological approach addresses multiple hallmarks of aging. 2) Selective activation of NaV1.3 restores lymphatic contractility in aging and injury (Ruscic et al., Massachusetts General Hospital, December 2025, https://www.biorxiv.org/content/10.64898/2025.12.15.694318v...

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  Episode #37

  Longevity Papers 2025-12-14

  Dec 14, 202535 minS0

  A Fourfold Male-Specific Lifespan Extension via Canonical Insulin/IGF-1 Signaling (Russell et al., University of Alabama at Birmingham, December 5, 2025, BioRxiv, https://www.biorxiv.org/content/10.64898/2025.12.02.691904v1 ) - We explore how the daf-2 mutation extends male C. elegans lifespan by an extraordinary 4-fold with preserved healthspan, establishing sex as a primary determinant of longevity potential rather than a secondary variable. This challenges our understanding of insulin/IGF-1 signaling and suggests sex-specific interventions may be critical for anti-aging therapeutics. 2) Lifespan-extending downregulation of insulin signaling reduces germline mutation load (Duxbury et al., University of East Anglia, December 5, 2025, BioRxiv, https://www.biorxiv.org/content/10.64898/2025.12.05.692572...

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  Episode #36

  AI, Splicing, and Nuclear Tension: 4 New Papers on Aging

  Nov 30, 202524 minS0

  In this episode, we analyze four standout papers from longevity research (November 17–30, 2025). The sources indicate that none achieve the paradigm-shifting breakthrough required for decades-long (10+ year) human lifespan extension. 1. Targeting Nuclear Tension to Rejuvenate Blood (Paper #74) Title: Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells Authors: Eva Mejía-Ramírez, Pablo Iáñez Picazo, Barbara Walter, et al. Source/Date: Nature Aging, November 25, 2025 URL: https://pubmed.ncbi.nlm.nih.gov/41286... This paper identifies a genuinely novel mechanotransduction axis (NE tension → P-cPLA2 → RhoA) in aging hematopoietic stem cells (HSCs). Aged HSCs accumulate pathological nuclear envelope (NE) tension, which hyperactivates RhoA signaling, leading to...

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  Episode #35

  Longevity Papers 2025-11-14

  Nov 14, 202513 minS0

  In this episode of Longevity Papers, we critically analyze the five most impactful papers from this week (November 10-14, 2025) selected from longevitypapers.com for biotech researchers and longevity enthusiasts. 1) 'circHERC1-A telomerase activator' (Yumeng Cui et al., Beijing Institute of Biotechnology, November 12, 2025, Science Advances, https://pubmed.ncbi.nlm.nih.gov/41223261/ ) - We explore how the circular RNA circHERC1 activates telomerase expression by recruiting RNA Pol II to the TERT promoter. Notably, circHERC1 declines with age, correlating with reduced telomerase activity. Restoration via AAV or extracellular vesicles enhances telomere elongation and reverses aging phenotypes including improved cognition and physical performance. This...

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