
Out Of Programme
Episode 36: Dr Nick Appelbaum on How Lord Darzi Changed His Career, Building the First Machine-Readable BNF, and Why Academic Projects Die Without Commercial Infrastructure
What happens when a South African surgeon gets plucked out by Lord Darzi, builds the first machine-readable BNF, and spins a company out of Imperial that reduces prescribing errors by 83%? In this episode, we speak with Dr Nick Appelbaum , a surgeon turned entrepreneur who went from inventing spreadsheet-based prescribing safety tools in South Africa to completing a PhD with Lord Ara Darzi at Imperial, leading clinical research at the Helix Centre, and founding Dosium β a company now integrating the BNF into NHS prescribing systems. How a "self-help program that grew out of hand" β inventing medication safety tools in South Africa's trauma centres β landed him a meeting with Lord Darzi οΈ Why Lord Darzi laughed at his plan to do an immunology PhD at Oxford and instead put him on the 10th floor at St Mary's to build something real The seven-year journey to create the first machine-readable British National Formulary, working with the Royal Pharmaceutical Society Founding Dosium and integrating the BNF into NHS electronic prescribing β reducing the odds of a medication error by 83% across deployed trusts Why "academic projects die without putting the infrastructure in place upfront" β and how the NIHR I4I grant forced the spinout decision The advice he wishes he'd had earlier: "find the suits, speak to the CFO, validate the economic proposition early β don't leave it to the last minute" Nick's story is a masterclass in turning a clinical frustration into a national infrastructure play, with the right mentorship and institutional backing. Follow us on: Substack LinkedIn βΆ YouTube Listen on: Spotify | Apple Podcasts



