Parallax by Ankur Kalra

See cardiology differently. Join Dr. Ankur Kalra for expert conversations exploring both the science and soul of cardiovascular care. Hear from legendary cardiologists and emerging leaders on clinical excellence, innovation, and the human experience of cardiology—burnout, spirituality, what it means to lead, and what it means to heal. Discover practical insights on GDMT optimization, heart failure management, interventional advances, and emerging research. Plus conversations on patient advocacy and the future of cardiology. Published every second Monday.Perfect for cardiologists seeking deeper understanding of their practice and profession.→ Rate & review on Apple Podcasts | Contact Ankur: podcast@radcliffe-group.com

Parallax by Ankur Kalra is a science podcast hosted by Radcliffe Cardiology, with 167 episodes on record and a Required Pod Score of 80.

Radcliffe Cardiology hosts Parallax by Ankur Kalra, a science show with 167 episodes published.

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  Parallax by Ankur Kalra

  EP 167: From Myosin Inhibitors to Sarcomere Modulators: The Next Era in HCM Care

  Sep 21, 202630 min

  In this episode of Parallax, Dr Ankur Kalra welcomes Dr Anjali Tiku Owens, Associate Professor of Medicine and Director of the Hypertrophic Cardiomyopathy Center at the University of Pennsylvania, for an in-depth discussion on one of the greatest unmet needs in hypertrophic cardiomyopathy (HCM): the treatment of symptomatic non-obstructive HCM. Together, they explore the complex pathophysiology driving symptoms in these patients, the limitations of traditional therapies, and the evolving understanding of chronotropy, inotropy and lusitropy in clinical decision-making. Dr Owens also shares insights from recent clinical trial data presented at ESC Congress 2025, highlighting emerging sarcomere-targeted therapies, including aficamten and the investigational agent EDG-7500. The conversation examines how these novel approaches may reshape treatment paradigms, improve functional capacity and address longstanding therapeutic gaps for patients with non-obstructive HCM, while offering a preview of where the field may be headed next. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts by Million Podcasts.

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  Parallax by Ankur Kalra

  Ep 166: Beyond the Lesion: Imaging, IVL and Modern Calcium Management

  Sep 7, 202646 min

  In this insightful episode of Parallax, Dr Ankur Kalra welcomes Dr Robert Riley, Director of Interventional Cardiology at Overlake Medical Center in Bellevue, Washington, for a masterclass on the contemporary management of complex PCI. Drawing on more than a decade of experience, Dr Riley explores how the field has evolved beyond technical success alone, with greater emphasis on patient selection, shared decision-making and aligning procedural goals with individual patient outcomes. The conversation takes a deep dive into the assessment and treatment of calcified coronary lesions, with a particular focus on the challenge of nodular calcium. Dr Riley shares his practical approach to intravascular imaging, lesion preparation and plaque modification, discussing when to utilise atherectomy, intravascular lithotripsy (IVL) and OPN balloons. He also highlights his growing use of drug-coated balloons in de novo lesions and provides insights into tailoring DAPT duration based on individual patient risk. For interventional cardiologists seeking actionable strategies to optimise outcomes in complex PCI, this episode offers invaluable clinical pearls from an experienced operator. How should operators approach heavily calcified lesions? When is atherectomy necessary, and where does IVL fit into modern practice? What role will drug-coated balloons play in the future of complex PCI? Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts by Million Podcasts.

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  Parallax by Ankur Kalra

  EP 165: Healing Hearts Through Ecosystems of Care

  Aug 24, 202628 min

  In this insightful episode of Parallax, Dr Ankur Kalra welcomes Dr Kim Smolderen, Professor of Medicine and Psychiatry at Yale University and psychologist at Yale New Haven Hospital, for a conversation on the growing field of cardiovascular psychology. Together, they explore how psychological well-being, medical trauma and social determinants of health influence cardiovascular outcomes, and why integrating these factors into routine cardiovascular care is essential for delivering truly patient-centred medicine. Dr Smolderen discusses the evidence linking anxiety, depression and PTSD to longer hospital stays, repeat procedures and increased healthcare utilisation. She shares her vision for creating "healing eco-systems" that bridge traditional clinical silos, bringing psychology and cardiology together through integrated care pathways, psychosocial risk assessment and trauma-informed care. The discussion also examines the business case for cardiovascular psychology, from reducing readmissions and emergency department visits to improving efficiency and enhancing the patient experience. As cardiovascular psychology continues to gain momentum globally, this episode highlights how whole-person care can benefit both patients and providers. Questions and comments can be sent to podcast@radcliffe-group.com and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts by Million Podcasts.

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  Parallax by Ankur Kalra

  EP 164: HFpEF in 2026: Phenotypes, Pathways and Precision Therapies

  Aug 10, 202651 min

  In this insightful episode of Parallax, Dr Ankur Kalra is joined by Dr Barry Borlaug, Professor of Cardiology at Mayo Clinic and one of the world's leading experts in cardiac haemodynamics, for a comprehensive discussion on the evolving landscape of heart failure with preserved ejection fraction (HFpEF). Together, they explore the complexities of diagnosing and managing a syndrome that continues to challenge clinicians. Dr Borlaug explains why exercise right-heart catheterisation remains the gold standard for uncovering "hidden" HFpEF, particularly in patients with normal resting filling pressures, and provides a detailed overview of the Mayo Clinic's invasive exercise testing protocol. The conversation also traces the evolution of HFpEF phenotyping, from the traditional hypertensive patient to the increasingly recognised obesity-driven phenotype, highlighting the role of systemic inflammation, visceral adiposity and disease progression across the HFpEF spectrum. Dr Borlaug outlines what he describes as the modern therapeutic backbone for HFpEF in 2026, reviewing the evidence supporting SGLT2 inhibitors, mineralocorticoid receptor antagonists including finerenone, and incretin-based therapies such as semaglutide and tirzepatide. Looking ahead, he discusses emerging investigational approaches including sotatercept, the challenges facing device-based therapies, and the importance of identifying HFpEF mimics such as cardiac amyloidosis and hypertrophic cardiomyopathy to ensure patients receive the most appropriate treatment. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

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  Parallax by Ankur Kalra

  EP 163: The Heart-Brain Connection: Rethinking Cardiac Risk

  Jul 27, 202650 min

  In this episode of Parallax, Dr Ankur Kalra is joined by Ms Claudia Garbrecht, psychologist specialising in psycho-cardiology and organisational health. Together, they explore the critical “heart–brain connection,” examining the high prevalence of anxiety and depression among patients with cardiovascular disease and the bi-directional relationship between mental health and cardiac outcomes. The discussion reframes traditional risk by highlighting the clinical importance of psychological distress, social isolation and behavioural factors in shaping cardiovascular risk and recovery. The conversation also turns to clinician wellbeing, with Ms Garbrecht outlining the impact of burnout, workplace stress and organisational culture on both physician health and patient outcomes. From the physiological effects of stress to the influence of communication and framing in consultations, this episode offers practical, time-efficient strategies to enhance patient interactions and reinforce positive behaviour. Dr Kalra reflects on applying these insights in practice, while Ms Garbrecht emphasises a fundamental principle: clinicians must prioritise their own wellbeing to deliver optimal care. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

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