The Cancer SIGNAL

Host Susanna Quinn explores topics relating to early cancer detection testing, including multi-cancer early detection testing, cancer genomics and risk, barriers to cancer screening, and much more.

The Cancer SIGNAL is a health podcast hosted by GRAIL, with 35 episodes on record and a Required Pod Score of 80.

GRAIL hosts The Cancer SIGNAL, a health show with 35 episodes published.

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  Episode #34

  34 - When Bile Duct Cancer is Found at Stage 1A: Melissa's Story

  Sep 9, 202621 minS1

  Melissa was healthy, had no worrisome symptoms, and never expected cancer to become part of her story. But after making the Galleri multi-cancer early detection (MCED) test part of her health routine, her second annual test returned a Cancer Signal Detected result with a predicted origin of liver/bile ducts. On this episode of The Cancer SIGNAL podcast, Melissa shares what happened next, including the diagnostic journey that would confirm her Stage IA cancer diagnosis. Melissa also reflects on the role her family played throughout treatment and recovery, and why her experience has strengthened her commitment to proactive health and early detection. Transcripts: https://grail.com/podcast/ Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/ The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests. See Important Safety Information: https://www.galleri.com/safety-information

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  Episode #33

  33 - Roger: A Pancreatic Cancer Survivor Story

  Aug 3, 202621 minS1

  Host Rayshawnda Madison connects with Roger, a returning guest who first shared his story in 2023 after receiving a Cancer Signal Detected result from the Galleri multi-cancer early detection (MCED) test. Follow-up testing led to a stage II pancreatic cancer diagnosis. Now, three years later, Roger reflects on how life has evolved since completing treatment, what survivorship looks like for him today, and the mindset that helped him move forward. He also shares how the experience changed his relationship with health, why he remains vigilant, and what motivates him to continue raising awareness about MCED testing. The overall sensitivity in study participants with pancreas cancer was 83.7%. (61.9% for stage I, 60.0% stage II, 85.7% stage III, 95.9% stage IV). The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests. Transcripts: https://grail.com/podcast/ Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/ See Important Safety Information: https://www.galleri.com/safety-information

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  Episode #32

  32 - NHS-Galleri Trial: One Participant's Journey Through Early Detection

  Jun 1, 202624 minS0

  <p>In this episode, Robert Higgs, a carpenter from the Midlands in England and a participant in the NHS-Galleri trial, joins host Shawnda Madison to share his experience.</p> <p>After enrolling in the trial, Robert received a Cancer Signal Detected result from the Galleri multi-cancer early detection (MCED) test despite having no symptoms. The initial diagnostic evaluation did not identify cancer, but a subsequent Galleri test the following year returned the same result, leading his care team to continue investigating.</p> <p>Eventually, a biopsy revealed a small HPV-related cancer at the base of his tongue. Robert reflects on...

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  Episode #31

  31 – When a Firefighter's Cancer Is Detected Early

  Dec 3, 202526 minS0

  <p > Kevin McFarland, a lieutenant with his local fire department, and Dr. Robert Merritt, a thoracic surgeon who helped diagnose and treat Kevin, share how the Galleri multi-cancer early detection (MCED) test unexpectedly revealed that Kevin had a signal for esophageal cancer—despite having no symptoms. The test, offered by the fire department where Kevin works, led to further medical exams that identified his specific type of cancer. Kevin reflects on the emotional, mental, and physical impact of his diagnosis and treatment, the importance of early detection, and how the experience renewed his appreciation for his health and family and ga...

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  Episode #30

  30 - PATHFINDER 2 study results from ESMO 2025 with principal investigator Nima Nabavizadeh, MD

  Oct 22, 202519 minS0

  <p > In this episode of The Cancer SIGNAL, Nima Nabavizadeh, MD, an associate professor of radiation medicine at Oregon Health & Science University (OHSU) and the chief medical officer at the Cancer Early Detection Advanced Research Center (CEDAR) at OHSU, joins host Susanna Quinn to share the results from the groundbreaking GRAIL PATHFINDER 2 clinical trial unveiled at the European Society for Medical Oncology (ESMO 2025) Congress. As the principal investigator for the trial, which examined the safety and performance of the Galleri multi-cancer early detection test, Dr. Nabavizadeh discusses why the findings are pivotal for patients and could potentially redefine early cancer d...

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