The Longevity Show with Dr. Hillary Lin

The Longevity Show with Dr. Hillary Lin breaks down complex medical concepts into easy-to-understand, actionable advice. We explore cutting-edge topics in preventative medicine, nutrition, metabolic health, exercise, and mental wellness - all aimed at helping you live a longer, healthier life.

The Longevity Show with Dr. Hillary Lin is a health podcast hosted by Hillary Lin, MD, with 103 episodes on record and a Required Pod Score of 80. PitchCentric scores this show on Booking Probability, Listen Score, and live audience signals refreshed every 24 hours.

Hillary Lin, MD hosts The Longevity Show with Dr. Hillary Lin, a health show with 103 episodes published.

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  The Longevity Show with Dr. Hillary Lin

  My LDL Was 192. Then I Found the First PCSK9 Pill.

  Aug 14, 202623 min

  My LDL was 192 even though I felt healthy. That result sent me into the story of PCSK9—a protein discovered outside cholesterol research that became the target of injections, RNA silencing, the first oral PCSK9 inhibitor, and now one-time gene-editing experiments. This episode follows the human genetics, LDL-receptor biology, and three engineering problems behind Lipfendra/enlicitide. The pill has proven potent LDL and ApoB lowering; its dedicated cardiovascular-outcomes trial is still ongoing. : . , , . Chapters : 00:00 The Inherited Risk: My LDL Was 192 and the First Oral PCSK9 Is Here 02:36 Nature’s Human Experiment: The Dallas Heart Study & The 88% Risk Drop 05:40 The Zero-PCSK9 Human: What Living with an LDL of 14 Proves 07:10 The Disposal Tag: How PCSK9 Destroys Your Artery Clearance 08:42 The Evolution of PCSK9 Inhibitors: From Antibodies to RNA 12:02 Evolution in a Test Tube: Engineering the First Oral PCSK9 Pill 16:04 The Practical Inversion: Why a Daily Pill Can Be Harder Than an Injection 18:04 One Injection for Life: The Promise and Risk of Permanent Gene Editing 21:12 What This Means for You: Managing Family History, Risk, and Daily Reality

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  The Longevity Show with Dr. Hillary Lin

  What Human Longevity Found After Screening 10,000 “Healthy” People

  Aug 4, 202618 min

  What happens when you run deep, whole-body imaging and genetic sequencing on 10,000 people who feel completely healthy? Dr. Wei-Wu He, Chairman and CEO of Human Longevity, Inc. (HLI), joins Dr. Hillary Lin to break down the realities of precision medicine and the hidden risks lurking in asymptomatic patients. They discuss why standard population medicine might miss your individual risk, how polygenic risk scores are changing cardiovascular prevention, and his vision for democratizing these life-saving screenings for everyone. About the Guest: Dr. Wei-Wu He is the Chairman and CEO of Human Longevity, Inc. (HLI), bringing over 40 years of experience in molecular biology and biotechnology to the forefront of proactive healthcare. A seasoned biotech entrepreneur and investor, his career has been dedicated to advancing genomics and precision medicine. Under his leadership, HLI is combining whole-genome sequencing, advanced imaging, and artificial intelligence to democratize data-driven, preventative medicine and extend the human healthspan. : - , ., . . - . Chapters: 00:00 What Happens When Healthy People Get Screened? 00:21 The Silent Risks: Aneurysms, Tumors, and Arterial Plaque 03:04 The Compound Effect of "Rare" Diseases 05:09 Lifespan Heritability: Is 50% of Your Life Predetermined? 05:48 Monogenic vs. Polygenic Risk Scores (PRS) 06:49 Predicting Heart Attack Risk 12 Years in Advance 10:52 Family History vs. Your Actual Genome 12:46 Inside HLI: The CEO's Vision for Data Collection 14:13 Case Study: Stool-DNA, Colonoscopy, and Appendiceal Cancer 17:04 Population Medicine vs. Individual Risk Dr. Lin's Longevity Tips & Newsletter: hillarylinmd.com/go/yt LinkedIn: linkedin.com/in/hillarylinmd About Dr. Hillary Lin: hillarylinmd.com Explore CareCore: carecore.io Human Longevity, Inc (HLI): https://www.humanlongevity.com/

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  The Longevity Show with Dr. Hillary Lin

  The Fitness Decline You Won’t See Coming (Even With “Good” Labs)

  Jul 20, 202655 min

  Your annual blood work looks perfect—but what happens when you hit a physical stressor, catch a virus, or simply start aging? Most standard labs are designed to detect disease, but they completely miss your physiologic reserve. In this episode, Dr. Hillary Lin sits down with Brooks Leitner to discuss why VO₂ max should be treated as a clinical vital sign. Using VO Health’s early-stage blood-based proteomics as a fascinating case study, we dive into how the body actually delivers oxygen under stress, why wearable estimates aren't the whole truth, and how you can actually build a "bad-day buffer" for your long-term health. What We’ll Cover The "Normal Labs" Trap: Why perfect blood work can hide dangerously low physical reserve. Your "Bad-Day Buffer": How to build resilience for unexpected physical stress like illness or surgery. The Missing Vital Sign: Why fitness should be checked right alongside your blood pressure. Oxygen Under Stress: What VO₂ max actually measures across your entire cellular engine. The Mortality Signal: The data linking higher fitness to a longer life, and what the studies really mean. VO₂ Max Blind Spots: Why cardio alone isn't enough to build true physical resilience. Data vs. Reality: Why mismatches between your smartwatch and your actual performance are valuable signals. Where to Start: A practical, zero-equipment method to start building your reserve today. Chapters 00:00 Why Normal Labs Miss The Mark 00:47 What Routine Blood Work Gets Wrong About Health 02:03 Defining True Resilience And Hormesis 04:34 The Shocking Decline In Population Fitness 06:32 Cardiorespiratory Fitness: The Missing Vital Sign 10:29 The Oxygen Cascade: How VO2 Max Actually Works 12:55 The Surprising Data Linking VO2 Max To Mortality 15:50 Improving VO2 Max: Is It Possible? 17:55 Weight Loss, Muscle Mass, And Gaming Your VO2 Max 23:54 Heart Rate Training Zones And The Problem With METs 29:21 Why Endurance Training Won't Maximize Your VO2 Max 32:00 What VO2 Max Completely Misses (Strength And Grip) 35:20 Sauna, Altitude, And Drugs For VO2 Max 42:08 Proteomics: Estimating Your VO2 Max From A Blood Test 49:00 Wearables and Their Accuracy in Measuring Fitness 51:53 The Ultimate Zero-Equipment Hack To Build VO2 Max Get Dr. Hillary Lin’s free longevity tips and newsletter: https://hillarylinmd.com/go/yt Learn more about the podcast: https://hillarylinmd.com/podcast LinkedIn: https://www.linkedin.com/in/hillarylinmd/ Learn more about Dr. Hillary Lin: https://www.hillarylinmd.com/ Explore CareCore: https://carecore.io VO Health: https://vohealth.co/

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  The Longevity Show with Dr. Hillary Lin

  High ApoB, CAC Zero: What Your Heart Tests Are Really Saying

  Jul 13, 20261h 11m

  High ApoB but clean metabolic labs. CAC zero but inherited Lp(a). A normal stress test but plaque on CCTA. This is where heart-disease prevention gets noisy. In this advanced episode, I walk through how I read conflicting heart-risk signals without letting one lab, scan, or internet camp hijack the whole conversation. The map is simple: particle traffic, the artery wall, blood pressure and metabolic terrain, visible plaque, and the clot we are trying to prevent. We cover ApoB, LDL-C, LDL-P, particle size, Lp(a), APOE4, CAC, CCTA, CIMT, stress testing, inflammation, plaque reversal, statin concerns, supplements, and what actually changes the next decision. Use this as education and a framework for better clinician conversations, not a personal treatment plan. Chapters 00:00 Why Heart Tests Seem To Disagree 01:43 The Map: Particles, Wall, Terrain, Plaque, Event 06:22 Where Plaque Actually Begins 10:07 Why Evolution Left Us Vulnerable 13:22 ApoB, LDL-C, LDL-P, Particle Size, Remnants, Lp(a) 25:54 High ApoB With Clean Metabolic Markers 30:51 Blood Pressure, Inflammation, And “Terrain” 35:37 APOE4, Family History, And Inherited Clues 40:38 CAC, CCTA, CIMT, Stress Tests, And AI Plaque Analysis 48:26 How To Read Conflicting Signals In Real Life 50:26 Plaque Reversal, Stabilization, And What Counts As Proof 54:18 Statins, Side Effects, Red Yeast Rice, And Supplement Claims 01:09:45 The Takeaway: Do Not Let One Marker Become The Whole Story

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  The Longevity Show with Dr. Hillary Lin

  Why One Hormone Test Can Miss the Whole Story

  Jun 10, 202642 min

  Hormones are not single data points. Cortisol, progesterone, testosterone, and other hormones change across the day, cycle, sleep, stress, training, and context.In this episode, Dr. Hillary Lin talks with Marina Pavlovic Rivas, cofounder and CEO of Eli Health, about why one annual lab snapshot can miss dynamic physiology — and why more data still needs humility.We cover: saliva testing and what it can/can’t show cortisol curves vs cortisol panic progesterone/testosterone tracking wellness data vs diagnostics why validated at-home testing is hard how AI in healthcare depends on better inputs Educational only, not medical advice. Chapters: 00:00 The Importance of Hormonal Health 00:54 The Data Gap in Hormone Health 02:43 The Science Behind At-Home Saliva Testing 06:17 Understanding Cortisol and Its Impact 12:14 Personalizing Cortisol Data vs. Wearable Tracking Limitations 15:05 Identifying Overtraining and "Tired but Wired" States 18:43 Expanding into Sex Hormones: Progesterone & Testosterone 20:40 Tracking Protocols: Finding Trends vs. Creating Noise 23:44 The "Anytime, Anywhere" Design Philosophy 24:40 Understanding Cortisol and Performance 28:31 Factors Influencing Testosterone Levels 31:36 Regulatory Boundaries: Wellness vs. Clinical Diagnostics 35:18 The Future of Data in Personalized Medicine 37:39 The Realities of Deep-Tech Health R&D 39:04 Closing Insights for Longevity and Health-Tech Founders Get Dr. Hillary Lin’s free longevity tips and newsletter: https://www.hillarylinmd.com/subscribe Learn more about Dr. Hillary Lin: https://www.hillarylinmd.com/ Explore CareCore: https://carecore.io

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