
Vital Flow
Local Anesthetics Part 4: LAST — When Local Anesthetics Become Toxic
<p>Episode Title</p><p>Local Anesthetics Part 4: LAST — When Local Anesthetics Become Toxic</p><p>Episode Description</p><p>In Part 4 of the Vital Flow Local Anesthetics series, we tackle one of the most important and potentially life-threatening complications of local anesthetic use: Local Anesthetic Systemic Toxicity, or LAST.</p><p>This episode walks through how LAST happens, which local anesthetics carry the greatest risk, and how toxicity progresses through the central nervous and cardiovascular systems. We’ll cover early warning signs, seizures, cardiovascular collapse, and why severe toxicity—particularly from bupivacaine—can be so difficult to treat.</p><p>Most i...

